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  Topic: John C. Sanford & John Baumgardner, OK Smart guys, help me out.< Next Oldest | Next Newest >  
Dr.GH



Posts: 2113
Joined: May 2002

(Permalink) Posted: Jan. 06 2008,18:01   

Is this just a retake on ReMine's BS?

http://a-c-s.confex.com/crops/2007am/techprogram/P35998.HTM

Monday, November 5, 2007
57-3
Using Mendel's Accountant to Simulate Mutation Accumulation and Genetic Load in Plants.
John C. Sanford, Horticultural Sciences, Cornell University, Geneva, NY 14456, John Baumgardner, Los Alamos National Laboratory (retired), Los Alamos, NM 87545, Paul Gibson, Int'l Inst. Cooperative Studies, Cooperative Studies Inc., PO Box 12830, Overland Park, KS 66282-2830, Wes Brewer, Computer Science & Electronic Engineering, Handong Global University, Handong, South Korea, and Walter ReMine, Science & Mathematics Dept., Northwestern College, St. Paul, MN 55113.

Long-standing theoretical concerns about mutation accumulation within higher organisms can now be addressed with numerical simulation. We have developed Mendel’s Accountant, which is a biologically realistic forward-time population genetics numerical simulation program. We have used this program to study mutation accumulation under a wide-range of circumstances. Using realistic estimates for the relevant biological parameters, we have investigated the rate of mutation accumulation, the distribution of the fitness effects of the accumulating mutations, and the overall effect on mean genotypic fitness. Our numerical simulations consistently show that deleterious mutations accumulate linearly across a large portion of the relevant parameter space. This appears to be primarily due to the predominance of nearly-neutral mutations. The problem of mutation accumulation becomes severe when mutation rates are high. Numerical simulations strongly support earlier theoretical and mathematical studies indicating that “genetic load” is a serious issue. Mendel's Accountant provides the opportunity to explore the relationship of mutation accumulation within the context of genetic resource preservation. Mendel also provides a practical basis for studying the basis of such things as hybrid vigor and numerous genomic evolutionary processes. Mendel's accountant can be downloaded free of charge at http://sourceforge.net/projects/mendelsaccount.  We welcome feedback and suggestions.

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"Science is the horse that pulls the cart of philosophy."

L. Susskind, 2004 "SMOLIN VS. SUSSKIND: THE ANTHROPIC PRINCIPLE"

   
ERV



Posts: 329
Joined: Sep. 2007

(Permalink) Posted: Jan. 06 2008,21:39   

You probably already know this, but just in case, Sanford is a YEC that spoke for ID at the KS kangaroo court.

  
Dr.GH



Posts: 2113
Joined: May 2002

(Permalink) Posted: Jan. 07 2008,08:08   

Quote (ERV @ Jan. 06 2008,19:39)
You probably already know this, but just in case, Sanford is a YEC that spoke for ID at the KS kangaroo court.

Sanford, Baumgardner and ReMine are all YECs.  I don't know anything about Paul Gibson, or Wes Brewer.

--------------
"Science is the horse that pulls the cart of philosophy."

L. Susskind, 2004 "SMOLIN VS. SUSSKIND: THE ANTHROPIC PRINCIPLE"

   
Art



Posts: 69
Joined: Dec. 2002

(Permalink) Posted: Jan. 07 2008,08:32   

Here is the paper that goes with the abstract.

   
slpage



Posts: 349
Joined: June 2004

(Permalink) Posted: Jan. 07 2008,08:35   

Quote (Dr.GH @ Jan. 06 2008,18:01)
Is this just a retake on ReMine's BS?

http://a-c-s.confex.com/crops/2007am/techprogram/P35998.HTM

Monday, November 5, 2007
57-3
Using Mendel's Accountant to Simulate Mutation Accumulation and Genetic Load in Plants.
John C. Sanford, Horticultural Sciences, Cornell University, Geneva, NY 14456, John Baumgardner, Los Alamos National Laboratory (retired), Los Alamos, NM 87545, Paul Gibson, Int'l Inst. Cooperative Studies, Cooperative Studies Inc., PO Box 12830, Overland Park, KS 66282-2830, Wes Brewer, Computer Science & Electronic Engineering, Handong Global University, Handong, South Korea, and Walter ReMine, Science & Mathematics Dept., Northwestern College, St. Paul, MN 55113.

Northwestern College is a Christians College....

The only place a hack like ReMine could get a job...

Interestingly, he is not mentioned in the Science and Mathematics faculty list, evan as a part-timer.  Hmmm....

  
Dr.GH



Posts: 2113
Joined: May 2002

(Permalink) Posted: Jan. 07 2008,09:31   

Quote (slpage @ Jan. 07 2008,06:35)
Northwestern College is a Christians College....

The only place a hack like ReMine could get a job...

Interestingly, he is not mentioned in the Science and Mathematics faculty list, evan as a part-timer.  Hmmm....

Maybe Walt can eat at their cafeteria.

--------------
"Science is the horse that pulls the cart of philosophy."

L. Susskind, 2004 "SMOLIN VS. SUSSKIND: THE ANTHROPIC PRINCIPLE"

   
Bob O'H



Posts: 2132
Joined: Oct. 2005

(Permalink) Posted: Jan. 07 2008,12:14   

Thanks for the link, Art.  I can't be bothered to go through it in detail right now, but mutation accumulation is something on which there's a decent literature (it relates to things like inbreeding, a big problem in Drosophila populations apparently).

A couple of years ago ReMine asked Leonard Nunney for some code Nunney had used to do some simulations on Haldane's dilemma.  Nunney refused, and ReMine got really upset, apparently unaware that he could read the paper and write his own code.  I mentioned this to someone at ESEB last summer, and the guy's reply was "Oh, so he's [ReMine] stupid and lazy".

Bob

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It is fun to dip into the various threads to watch cluelessness at work in the hands of the confident exponent. - Soapy Sam (so say we all)

   
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